Key matchup: Dolphins offensive line vs. Bills defensive line. Both units have had their moments this season. In the first game, the Bills won this battle. The Dolphins ran 24 times for 60 yards (2.5-yard average). Ryan Tannehill was sacked three times. Especially with questions about the Dolphins receivers' health, this is a battle the Dolphins need to win. One matchup to watch is Mario Williams, who started slow but has 10.5 sacks, including six in the last five games, lining up against right tackle Nate Garner.